End User Computing Engineer ID-19966
4DMT is a clinical-stage biotherapeutics company harnessing the power of directed evolution for targeted genetic medicines. We seek to unlock the full potential of gene therapy using our platform, Therapeutic Vector Evolution (TVE), which combines the power of directed evolution with our approximately one billion synthetic AAV capsid-derived sequences to invent evolved vectors for use in our products. We believe key features of our targeted and evolved vectors will help us create targeted product candidates with improved therapeutic profiles. These profiles will allow us to treat a broad range of large market diseases, unlike most current genetic medicines that generally focus on rare or small market diseases.
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We have built a deep portfolio of AVV-based gene therapy product candidates, with five product candidates in clinical trials: 4D-150 for the treatment of wet age-related macular degeneration (wet AMD) and diabetic macular edema (DME), 4D-710 for the treatment of cystic fibrosis lung disease, 4D-310 for the treatment of Fabry disease cardiomyopathy, 4D-125 for the treatment of X-linked retinitis pigmentosa (XLRP), and 4D-110 for the treatment of choroideremia. In addition, we have two product candidates in preclinical studies: 4D-175 for geographic atrophy (GA) and 4D-725 for alpha-1 antitrypsin deficiency.
To-date, we have demonstrated clinical proof-of-concept for three evolved vectors in three therapeutic areas and routes of administration with five products and patient populations. We believe this validates the power of our directed evolution platform for discovering superior vectors compared to wildtype viral vectors. We have built a robust and efficient product engine with 6 open Investigational New Drug Applications (INDs) in the U.S., 1 IND in Taiwan, and 1 Clinical Trial Approval (CTA) in Australia. We believe we are positioned to create, develop, manufacture and, if approved, effectively commercialize targeted genetic medicines that could transform the lives of patients suffering from debilitating diseases.
In addition to TVE, our technology includes a robust AAV manufacturing platform and onsite manufacturing facility that allows us to rapidly produce and test research grade material and scale up to GMP clinical material. This internal capability and close collaboration between our R&D and Manufacturing teams has greatly accelerated the pace of discovery at 4DMT.
Company Differentiators:
• Fully integrated clinical-phase company with internal manufacturing
• Demonstrated ability to move rapidly from idea to IND
• Five candidate products in the clinic and two declared pre-clinical programs
• Robust technology and IP foundation, including our TVE and manufacturing platforms
• Initial product safety and efficacy data substantiates the value of our platforms
• Opportunities to expand to other indications and modalities within genetic medicine
GENERAL SUMMARY:
We are seeking a highly skilled and experienced End User Computing (EUC) Engineer to join our dynamic team. In this role, you will be responsible for planning, designing, implementing, and supporting end user computing infrastructure to ensure a secure, reliable, and productive computing environment for our organization.
*This is a 6 - 12 assignment, local candidate required*
RESPONSIBILITIES:
The EUC Engineer is responsible for the management of 4DMT’s:
- IT endpoint infrastructure & enterprise end user services
This Information Technology role reports to the head of IT Operations & Security.
Essential Duties & Responsibilities
- Design, implement, and manage end user computing solutions, including desktop/laptop systems, mobile devices, virtual desktop infrastructure (VDI), and productivity/business applications.
- Deploy and configure operating systems (Windows, macOS) and ensure compatibility with organizational requirements and security standards.
- Develop and maintain system images and software packages using automated deployment.
- Manage and maintain end user computing infrastructure, including hardware, software, and peripherals.
- Monitor system performance, troubleshoot issues, and optimize resource utilization.
- Implement security measures to protect end user devices and data, including encryption, access controls, and antivirus solutions.
- Ensure compliance with regulatory requirements and industry best practices.
- Provide technical support to end users, including troubleshooting hardware and software issues, and resolving technical problems in a timely manner.
- Develop and maintain knowledge base articles, user guides, and training materials to empower end users and promote self-service support options.
- Interact with cross-functional IT teams to assess end user computing needs and develop strategic plans for technology adoption and integration.
- Communicate effectively with stakeholders at all levels of the organization to gather requirements, provide updates, and solicit feedback.
- Participate in technology evaluations and recommend solutions that align with business objectives and budget constraints.
- Maintain accurate documentation of end user computing configurations, procedures, and policies.
- Ensure compliance with IT policies, standards, and procedures, and participate in audits as required.
- Stay abreast of emerging technologies and industry trends related to end user computing and evaluate their potential impact on the organization.
- Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties & responsibilities to this job at any time.
QUALIFICATIONS:
Experience:
- 7+ years' experience as EUC engineer in highly regulated, complex and multi-vendor environments (e.g. Financial, Pharma)
- 5+ years' experience managing desktop and server OS and application patching and application packaging using sophisticated management systems (e.g. Intune, System Center Configuration Manager)
- 6+ years' experience managing Virtual Desktop environments, Mobile Device Management Systems (e.g. MS Intune) and Endpoint protection systems (e.g. SEP)
- 7+ years' experience supporting Windows Enterprise customers in a large-scale (300+ node) environment.
- 5+ years biopharmaceutical experience in fast-growing environment.
- Industry recognized technical level education & experience.
- Office environment with daily onsite presence required.
Skills:
- Successful track record of EUC architecture and administration, execution, and delivery.
- Ability to multi-task in a fast-paced, dynamic environment.
- Experience working in a regulated networking environment (SOX and 21CFR11).
- Excellent organizational, communication and customer service skills with active-listening skills.
- Proven adaptability to shifting project schedules, priorities, and assignments; able to make effective decisions under pressure.
- Demonstrated problem-solver with the ability to cope under pressure and coordinate multiple activities in a dynamic, fast-paced team environment.
- Excellent written and documentation skills including proof reading and attention to detail.
- Hands-on experience with hardware and software troubleshooting, system imaging, and software deployment tools.
- Must be a self-driven, motivated IT professional with strong analytical and problem-solving skills, and ability to diagnose and resolve complex technical issues.
- Excellent communication and interpersonal skills, with the ability to work effectively in a team environment and interact with diverse stakeholders including executive management.
- Proactively identify opportunities for process improvements and automation to streamline end-user support services.
- Proficiency in operating systems (Windows, macOS, Linux), desktop virtualization technologies (e.g., Citrix Virtual Apps and Desktops), and endpoint management solutions (e.g., Microsoft Intune, SCCM, Tanium), M365, Okta, Active Directory, etc.
